Cystatin C is made by all nucleated cells, not just muscle. As a result, cystatin C production varies less than creatinine production between individuals, and blood concentrations of cystatin C are fairly similar between individuals who have the same GFR. However, cystatin C has other potential confounders. For example, chronic inflammation.
Summary Because measurements of GFR are tedious, estimated GFRs based on creatinine or cystatin C are widely used for assessing kidney function. Both measured GFRs and the Staging System for CKD based on GFR have analytical and clinical shortcomings. The advantages of serum creatinine and cystatin C, and eGFR will be discussed.
Compared with creatinine, cystatin C is better correlated with GFR and is a more accurate predictor of several clinical outcomes.7, 8, 9 Cystatin C is a 13.3 kDa cysteine protease inhibitor produced by all nucleated cells. 10 It is freely filtered across the glomerular membrane, reabsorbed, and catabolized by the tubules.11, 12, 13 The serum level of cystatin C is also influenced by nonrenal.
Cystatin C or cystatin 3 (formerly gamma trace, post-gamma-globulin, or neuroendocrine basic polypeptide), a protein encoded by the CST3 gene, is mainly used as a biomarker of kidney function.Recently, it has been studied for its role in predicting new-onset or deteriorating cardiovascular disease.It also seems to play a role in brain disorders involving amyloid (a specific type of protein.
Salvatore Di Somma, Rossella Marino, in Critical Care Nephrology (Third Edition), 2019. Cystatin C. Cystatin C or cystatin 3 (formerly gamma trace, post-gamma-globulin, or neuroendocrine basic polypeptide) has been proposed as a valuable alternative marker tested in urine and in blood, particularly in situations in which creatinine-based estimates of GFR fail to provide an accurate estimate.
In critically ill patients sudden changes in glomerular filtration rate (GFR) are not instantly followed by parallel changes in serum creatinine. The aim of the present study was to analyze the utility of serum cystatin C as a marker of renal function in these patients. Serum creatinine, serum cystatin C and 24-hour creatinine clearance (CCr) were determined in 50 critically ill patients (age.
A cystatin C test may be used as an alternative to creatinine and creatinine clearance to screen for and monitor kidney dysfunction in those with known or suspected kidney disease.It is most useful in special cases where creatinine measurement could be misleading. For example, in those who have liver cirrhosis, are very obese, are malnourished, practice a vegetarian diet, have amputated limbs.
The net reclassification improvement with the measurement of cystatin C, as compared with creatinine, was 0.23 (95% confidence interval (CI), 0.18 to 0.28) for death and 0.10 (95% CI, 0.00 to 0.21.
Cystatin C is not affected by muscle mass or diet and is less strongly associated with age, sex, and race than creatinine, but smoking, inflammation, adiposity, thyroid diseases, malignancy, and glucocorticoids influence cystatin C levels, diminishing their value as a measure of renal excretory performance. 5 In addition, international standardization of the cystatin C assay is not finalized.
We compared the association of the eGFR, as calculated by the measurement of creatinine or cystatin C alone or in combination with creatinine, with the rates of death (13,202 deaths in 15 cohorts), death from cardiovascular causes (3471 in 12 cohorts), and end-stage renal disease (1654 cases in 7 cohorts) and assessed improvement in reclassification with the use of cystatin C.
Chronic kidney disease affects over 10 percent of adults worldwide. The researchers note that, unlike creatinine, cystatin C is not affected by muscle mass, so it requires less adjustment for factors like age and gender. In addition, cystatin C works similarly as a marker of kidney function in blacks and whites.
Measuring blood levels of the protein cystatin C can help identify individuals with chronic kidney disease (CKD) who have a poor prognosis, new research finds (Peralta CA, et al. Cystatin C identifies CKD patients at higher risk for complications. J Am Soc Nephrol, Janaury 2011). “The manuscript nicely describes potential methods for incorporation of cystatin C into clinical.
What is cystatin C? Cystatin C is a protein that is produced by the cells in your body. When kidneys are working well, they keep the level of cystatin C in your blood just right. If the level of cystatin C in your blood is too high, it may mean that your kidneys are not working well. A blood test for cystatin C can help your healthcare provider find your GFR (glomerular.
Conclusion:Serum cystatin C prove more useful in monitoring the function of kidney allograft with proteinuria compared to serum creatinine. The combination of serum creatinine and serum cystatin C (CKD-EPI creatinine cystatin C 2012) is more accurate than either marker alone for estimating GFR.
Serum cystatin C as a marker of glomerular filtration rate Curr Opin Nephrol Hypertens. 2006 Nov;15(6):610-6. Inker LA, Schmid CH, Tighiouart H, Eckfeldt JH, Feldman HI, Greene T, Kusek JW, Manzi J, Van Lente F, Zhang YL, Coresh J, Levey AS; CKD-EPI Investigators. Estimating glomerular filtration rate from serum creatinine and cystatin C.
OBJECTIVE Serum cystatin C is an alternative to serum creatinine for estimating glomerular filtration rate (GFR), since cystatin C is less influenced by age and muscle mass. Among persons with diabetes, we compared the performance of GFR estimated using cystatin C (eGFRcys) with that using creatinine (eGFRcr) for the identification of reduced kidney function and its association with diabetes.
Background: Serum cystatin C (Cys C) has been proposed as a simple, accurate, and rapid endogenous marker of glomerular filtration rate (GFR) in research and clinical practice. However, there are conflicting reports regarding the superiority of Cys C over serum creatinine (Cr), with a few studies suggesting no significant difference. Methods: We performed a meta-analysis of available data from.
Adult reference ranges for serum cystatin C, creatinine and predicted creatinine clearance Hazel Finney1, David J Newman2and Christopher P Price1 Fromthe1Department of Clinical Biochemistry, St Bartholomew’s and The Royal London School of Medicine and Dentistry, Turner Street, London E1 2AD, and the2SW Thames Institute for Renal Research, St Helier NHS Trust, Wrythe Lane, Carshalton, Surrey.
Glomerular filtration rate (GFR) is considered the best marker of renal function, and its estimation using inulin or 51Cr-EDTA is considered the “gold standard.” Such determination is inconvenient and often replaced by an estimate of creatinine clearance (CrCl) derived from the formula of Cockroft and Gault (CG). Serum cystatin-C was recently proposed as a reliable alternative routine.